You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family's personal health. Surg Neurol Int. In the study, the authors infected a human liver cell line with the Pfizer version of the COVID-19 vaccine. Pfizers COVID trials6 enrolled 46,331 participants in a Phase 3 clinical trial while Recombivax HB tested just 147 infants and children. Skip to main content. Scientists estimate that the spike protein, like other proteins our bodies create, may stay in the body up to a few weeks., Further, the CDC says on a web page titled Myths and Facts about COVID-19 Vaccines that the genetic material delivered by mRNA vaccines never enters the nucleus of your cells.. Second, they measured LINE-1 activity. Both boys were pronounced dead at home. BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. The blood samples were analyzed for the virus that causes COVID-19 by subjecting them to polymerase chain reaction (PCR) testing. The whole process occurred rapidly within six hours. Well do this by highlighting a few papers that caused fear, generated confusion, or spread misinformation by looking at the interpretation, what it was based on, and why it was not correct. Parents PACK May 2022, Feature Article. WebPfizer Vaccine Becomes DNA in Liver Cells. Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. At the heart of the misconceptions about this paper is figure 1, which shows viral shedding among vaccinated (green) and unvaccinated (red) individuals. As such, finding similar stretches of genes is not novel, unlikely, or particularly surprising. First, cancerous cell lines replicate, whereas our liver cells typically are not replicating. Why liver cells and why the specific dose? 2022 Apr 11;44(4):1661-1663. doi: 10.3390/cimb44040113. Microbiol Spectr. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage 2020;383:24392450. Social media users are falsely claiming that a Swedish study conducted by Lund University found that mRNA COVID-19 vaccines permanently alter human DNA. Huh7 cells were treated without (Ctrl) or with 0.5, 1, and 2 g/mL of BNT162b2 for 6 h. Cells were fixed and stained with antibodies binding to LINE-1 ORF1p (red) and DNA-specific probe Hoechst for visualization of cell nucleus (blue). The content provided in this video is for informational and educational purposes only.\rPlease consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. 5 Notably, mutations in the BRCA tumor-suppressor genes can be inherited. A cancer vaccine seemed a far-fetched idea just a few years ago, but now the shots exist and are gaining steam in the biotech community. Salesforce has already slashed 8,000 workers from its ranks this year. J Transl Autoimmun. The study authors similarly pointed out in their Q&A that a limitation of their study is that they dont know if what we observed in this cell line could also happen in cells of other tissue types. They stated that this would need to be addressed in follow-up studies. WebRead about Pfizer Vaccine Becomes DNA in Liver Cells. We have a new vaccine, and it needs to be tested in cell and animal models and also in humans, in various ways. Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. YDM: A previous study from MIT has indicated that the SARS-CoV-2 virus mRNA can be converted to DNA and integrated into the human genome. The researchers write that the findings warrant a further -, Polack F.P., Thomas S.J., Kitchin N., Absalon J., Gurtman A., Lockhart S., Perez J.L., Perez Marc G., Moreira E.D., Zerbini C., et al. May 03, 2022 Drugs and Lactation Database (LactMed) [Internet]. Our publication is the first in vitro study on the conversion of mRNA vaccine into DNA, inside cells of human origin. The results have been widely discussed across social media but the results have in many cases been misinterpreted. Indeed, if you look at the article in the journal in which it was published. Bad Bunny. Let's review.\r\rIf you like this content and want more, I am doing a special lifetime membership offer. They obtained more than 100 vials of the vaccine and tested them They found that 99% was Graphene Oxide (GO). Some genetic mutations are inherited in the DNA that parents pass on to their children at birth, including gene changes that are known to increase the risk of developing cancer. You can unsubscribe at any time and we'll never share your details to third parties. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. J. Med. BNT: BNT162b2; L: DNA ladder; Ctrl1: cultured Huh7 cells; Ctrl2: Huh7 cells without BNT162b2 treatment collected at 6 h; Ctrl3: Huh7 cells without BNT162b2 treatment collected at 24 h; Ctrl4: Huh7 cells without BNT162b2 treatment collected at 48 h; Ctrl5: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h; Ctrl6: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h, digested with RNase. Safety and Immunogenicity of Two RNA-Based COVID-19 Vaccine Candidates. Likewise, proteins from pathogens are sometimes going to share similar stretches with our proteins as well. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. doi: 10.1056/NEJMc2107717. One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies, de Marinis said. Turn on javascript for best performance. Comment on Aldn et al. While the Moderna vaccines are meeting this specification, the Pfizer vaccines are 10 fold higher in contamination with 1 DNA molecule per 350 mRNAs. 2022 The Childrens Hospital of Philadelphia. 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The authors declare no conflict of interest. 5. Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line. And, while this may be the case early during infection, there are a few additional considerations when thinking about these data: Hopefully these examples demonstrated some of the ways that a paper should be examined. (In-vitro Swedish Study) https://youtube.com/live/MjxlvduyJyc?feature=share 28 Feb 2023 02:39:58 WebFew vaccines have been launched for this purpose recently with different side effects. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. Disclaimer. During the study, the researchers were able to detect DNA that had been converted from the vaccines mRNA in the lab-modified cell. Daily science news on research developments and the latest scientific innovations, The latest engineering, electronics and technology advances, The most comprehensive sci-tech news coverage on the web. 8600 Rockville Pike We show that the vaccine enters liver cells as As we discussed in, The quantity of a genetic tool called LINE-1, The presence of DNA sequences similar to the vaccine RNA in the nuclei of these cells, Perhaps most importantly, this experiment was done on cells being grown in a lab. Further, the newest vaccines are personalized, meaning they can target a patients WebPrevious vaccines were largely attenuated or live vaccines that were bioengineered to not cause as severe of a reaction while still being similar enough to the origin virus to cause us to gain immunity. These vaccines deliver genetic material that instructs cells to begin making spike proteins found on the surface of SARS-CoV-2 that causes COVID-19 to produce an immune response. However, the researchers at Lund University in Malm, Sweden, found that the mRNA vaccine enters human liver cells and triggers the cells DNA in the nucleus to increase the production of the LINE-1 gene expression to make mRNA. Clin Microbiol Infect. About BVHS; Mayo Clinic Care Network; News & Media; Contact Us Our COVID-19 vaccine does not alter the DNA sequence of a human cell, a Pfizer spokesperson told The Epoch Times in an email. Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines. Moore also cautioned that the cells used in the study were quite different than primary cells in the body. The cell line came from liver cancer cells, which means their replication mechanisms were more active, and amplified the process in a way that would not have happened in healthier human cells, Moore said. Data, especially data from vaccinated humans, will hopefully sort out the question marks. Current Issues in Molecular Biology. But keep in mind, when the mRNA or adenovirus particles do hit cells outside of the liver or the site of injection, they're still causing them to express Spike protein anchored on their surfaces, not dumping it into the circulation. Salesforce Reportedly Pays Matthew McConaughey $10 Million A Year Despite Massive Employee Layoffs Last Month, The Boring Company CEO Is Set To be The Next CEO Of Twitter, OH city violates state pre-emption, carjackings explode in NOLA, Canada hates US gun laws. 2021 Jun 7;22(5):172. doi: 10.1208/s12249-021-02058-y. MR: We understood that the study would attract attention, but we think it is self-evident that this type of research should be pursued. More than 215 million or 64.9 percent of Americans are fully vaccinated as of Feb. 28, with 94 million having received a booster dose. Pfizers covid jab contents enter the liver, alter human chromosomes and rewrites DNA. Further, the newest vaccines are personalized, meaning they can target a patients Thrombotic events have been reported as a rare side effect after ChAdox1nCOV-19 vaccination that may cause death of recipient. Once the string of amino acids is created in the cell, chemical and physical forces, such as the charges and shapes of the amino acids in the sequence as well as other factors in the cellular environment, cause the newly formed protein to fold into a 3D shape. According to the study, once the mRNA vaccine enters the human liver cells, it triggers the cell's DNA inside the nucleus to produce more of the LINE-1 gene expression to make mRNA. Associate Professor 2023 Jan 4;45(1):400-433. doi: 10.3390/cimb45010028. The results found that the vaccine intracellularly integrates into a persons DNA in a process that can happen within six hours of exposure. They used different concentrations of the vaccine and multiple timepoints to measure: Some pointed to this paper as proof that COVID-19 vaccines alter DNA. This, of course, does not mean these data are not important. Keywords: Therefore, most scientists were critically monitoring data for any potential issues as COVID-19 vaccines were developed. 2022 Feb 28;194(8):E297-E305. (. Five patients (42 percent) were evaluated for liver transplantation because of persistent jaundice, hepatic insufficiency, and/or recurrent cholangitis. Dr. Peter McCullough, an internist, cardiologist, and epidemiologist,wrote on Twitterthat the Swedish studys findings have enormous implications of permanent chromosomal change and long-term constitutive spike synthesis driving the pathogenesis of a whole new genre of chronic disease.. Table S1 summaries the vaccines Materials in this section are updated as new information and vaccines become available. Drugs and vaccines used for treating and preventing coronavirus infection also have hepatotoxicity. (In-vitro Swedish Study) An accepted and published Swedish study demonstrates for the official website and that any information you provide is encrypted N. Engl. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. DOI: 10.3390/cimb44030073. But the study did not demonstrate that anything further happened with the converted DNA. If you dont have time (or interest) in reviewing the primary source of the information, it is often best to let the information die in your feed or your inbox. Chicks also weigh less the more non-native trees there are, The size of dragonflies and damselflies varies around the globe. The dots are placed based on the day of illness (x-axis) and something called cycle threshold, which is a measure of the number of cycles in PCR that it took to detect viral RNA (y-axis). Webhttps://lnkd.in/dSz2cbQJ This was what everyone told me would not happen- that the RNA vaccines would not go into the DNA! Lund University The content is provided for information purposes only. eCollection 2022 Dec. Mavridis C, Aidonidis G, Evangelou M, Kalogeridis A. Hist Philos Life Sci. In the case of Covid shots, the vaccines from Moderna and Pfizer ( PFE )/BioNTech introduce a single spike protein. Huh7, MeSH :\rBuy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed\rBecome my patron: https://www.patreon.com/mobeensyed?fan_landing=true\rPayPal: https://paypal.me/mobeensyed?locale.x=en_US\r\r#drbeen #koolbeens #COVID\r\rDisclaimer:\rThis video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. Published on The Swedish study suggests the vaccine is capable of becoming DNA, which is what the CDC claimed WebImmunogenicity after SARS-CoV-2 vaccination is known to be impaired in liver transplant (LT) recipients, but the results after the application of a third dose show significant improvement in seroconversion rates. Study: Pfizer Covid Vaccine Converts to DNA Inside Liver Cells. Epub 2022 Nov 10. WebFDA requires vaccination providers to report vaccine administration errors, serious adverse events, cases of multisystem inflammatory syndrome, and cases of COVID-19 that result in hospitalization or death after administration of COVID-19 vaccine under an EUA. Spetzofai is a rustic spicy Greek dish that is made with thick sausages and long green and red peppers in a rich tomato sauce. This document is subject to copyright. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. The messenger RNA (mRNA) from Pfizer s COVID-19 in The mean time from COVID-19 diagnosis to cholangiopathy was 118 days. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult your physician or, in serious cases, seek immediate assistance from emergency personnel. Likewise, the Results section has five sentences. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Genomics, diabetes and endocrinologyyang [dot] de_marinis [at] med [dot] lu [dot] se, Box 117, 221 00 Lund, Sweden WebThe interaction between pre-existing liver disease and coronavirus infection has been illustrated, whereby coronaviruses influence the occurrence, severity, prognosis and treatment of liver diseases. 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