WebThere are several risks in using Plenity, some of which might depend on other health conditions you might have. 50 mg Tablet: light pink, square pyramid tablet debossed with "W" over "50" on the flat side Hypersensitivity to desvenlafaxine succinate, venlafaxine hydrochloride or to any excipients in the PRISTIQ formulation. If you have a Their average weight loss was 10% (about 22 pounds). If you cannot use the above website or would like to report an adverse event related to a different Pfizer product, please call Pfizer Safety at (800) 438-1985. Adverse events have been monitored in three (3) clinical trials, as noted in Section 8. cellulose/ citric acid hydrogel No research has been performed to determine whether Plenity has a significant impact on obesity-related comorbidities such as type 2 diabetes mellitus, cerebrovascular disease, coronary artery disease, and chronic kidney disease. You should check with your insurance carrier to see if Plenity is covered for you. If you miss a pre-meal dose, take Plenity with 16 oz. No gimmicks, just science-backed resources to help support your weight management journey. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor. Because its mechanism of action is mechanical, Plenity is considered a medical device rather than a drug. Our scientific content is evidence-based, scientifically balanced and non-promotional. Prescription drug and vaccine pricing may vary depending on the pharmacy and Inside Rx users are responsible for paying the discounted cost of their prescription(s), including vaccine administrative fees, where applicable. Reduce the dose of these drugs by up to one-half if co-administered with 400 mg of PRISTIQ. BMI is calculated using your weight (in lb.) For a full list of Inside Rx program terms see full terms or call 800-722-8979. Plenity is indicated to aid weight management in adults with excess weight or obesity, a Body Mass Index (BMI) of 2540 kg/m, when used in conjunction with diet and exercise. Plenity costs $98 for a 4-week supply ($1.75 per meal). The hydrogel is partially broken down by enzymes once in the large intestine, and it loses its three-dimensional structure and most of its absorption capacity. OSH functions primarily through space occupancy in the stomach and small intestine. Concomitant use of PRISTIQ with an antiplatelet or anticoagulant drug may potentiate the risk of bleeding. 12/2021, https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/english_bmi_calculator/bmi_calculator.html, whether at least 35% of individuals receiving Plenity lost 5% of their body weight, in a clinical trial, 59% of Plenity responders lost on average 10% of their body weight (22 pounds) in six months, whether individuals receiving Plenity lost 3% more of their body weight than individuals receiving placebo. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. These side effects include: Stomach pain or upset stomach Oily discharge from the anus Gas with oily anal discharge Oily stools More-frequent bowel movements Urgent or hard-to-control bowel movements Other possible side effects include: Headache Back pain Common cold eCollection 2022 Jun. Sign in to view your previously saved lists. Plenity is NOT available at retail pharmacies. A few simple additions or swaps can help you feel fuller and more satisfied. Significantly more patients treated with Plenity (59% vs. 42% with placebo) achieved a weight loss of at least 5%, and 27% (vs. 15% with placebo) lost at least 10% of their body weight. These medications may cause some risk when taken together. Confirmatory tests, such as gas chromatography/mass spectrometry, will distinguish desvenlafaxine from PCP and amphetamine. Check for drug interactions and save your list for future reference. HHS Vulnerability Disclosure, Help The capsule for Plenity is made with gelatin, which is a porcine-derived product. Plenity is not absorbed into the bloodstream. Contact a doctor right away if problems occur. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. The concomitant use of SSRIs and SNRIs including PRISTIQ with MAOIs increases the risk of serotonin syndrome. In a clinical study,* nearly 6 out of 10 people who took Plenity lost at least 5% of their body weight. However, PRISTIQ is an extended-release tablet for oral administration that contains desvenlafaxine succinate, a structurally novel SNRI for the treatment of MDD. Contact a doctor right away if problems occur. This third-party website is neither owned nor controlled by Pfizer, and Pfizer does not endorse and is not responsible for the content or services of this site. To get Plenity, visit MyPlenity.com to start an online consultation. A clinical study has shown that PRISTIQ does not increase the impairment of mental and motor skills caused by ethanol. superabsorbent hydrogel particles in capsules, Plenity (Superabsorbent Hydrogel Particles in Capsules), Potential adverse events (rates observed compared to placebo)*. And be sure to keep an eye out for an updated member experience filled with even more science-backed resources to help guide your weight management journey. Last updated by Judith Stewart, BPharm on May 13, 2019. The most common side effects were fullness, bloating, flatulence, and/or abdominal pain. It will also display any interactions between your chosen drug(s) and food, beverages, or a medical condition. You may report side effects to FDA at 1-800-FDA-1088. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Generic name: cellulose and citric acid Brand name: Plenity Some medications may be better absorbed if taken with food or may have more favorable blood levels if taken with other medications that affect metabolic enzymes. Data synthesis: Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. doi: 10.1002/14651858.CD008650.pub2. monograph. Data synthesis: OSH is a first-in-class, nonsystemic agent for weight management. Major drug interactions that are life-threatening are not common, but are of serious concern. Plenity should be kept in its original pod until use. It is an FDA-cleared medical device available only by prescription. Dietary fibers, on the other hand, have linear structure and when hydrated they carry water only on their surface. Please e-prescribe Plenity to GoGoMeds Pharmacy in Southgate, KY, or fax to (877) 766-0185. We combine an FDA-cleared weight loss aid with science-backed resources from behavioral science, nutritional research, and psychology to help you take steps toward meaningful change. and transmitted securely. Treatment for: Weight Loss (Obesity/Overweight). FDB disclaims all warranties, whether expressed or implied, including any warranty as to the quality, accuracy, and suitability of this information for any purpose. Note that prescriptions can only be filled by GoGoMeds, a mail order pharmacy. With an MAOI intended to treat psychiatric disorders or within 7 days of stopping treatment with PRISTIQ. Contact a doctor right away if problems occur. All rights reserved. The INSIDE RX mark is owned by Express Scripts Strategic Development, Inc. Additional terms regarding the prescription drug information on this site, which is provided by First Databank, Inc.: The information contained in the First Databank (FDB) databases is intended to supplement the knowledge of physicians, pharmacists, and other healthcare professionals regarding drug therapy problems and patient counseling information. Careers. This action works to create increased bulk, thus signaling satiety. However, as with all CNS-active drugs, Plenity may affect how well your body absorbs other medications. The https:// ensures that you are connecting to the Save up to 80% on brand & generic medications. Weve made it easy to see if you qualify! Cheat meals and cheat days might feel like a well-earned reward, but they may be doing more harm than good when youre trying to make sustainable lifestyle changes. Do I need to see a doctor in person to get Plenity? These highlights do not include all the You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns either online at. Relevance to patient care and clinical practice: Submit a medical question for Pfizer prescription products. Developed, clinically tested, and manufactured by Gelesis. 25 mg Tablet: tan, square pyramid tablet debossed with "W" over "25" on the flat side. settings and refresh the page. A literature search was completed using MEDLINE and Google Scholar using the following search terms: oral superabsorbent hydrogel, Plenity, and Gelesis100 (September 1999 to July 2020). This content is intended for U.S. Healthcare Professionals. This may be due to the effect of PRISTIQ on the release of serotonin by platelets. Copyright 2023 American Academy of Family Physicians. If you miss a pre-meal dose, take Plenity with 16 oz. Recent advances in therapies utilizing superabsorbent hydrogel technology for weight management: A review. Plenity (cellulose and citric acid) is an oral capsule that promotes fullness and may help to increase satiety to help patients manage their weight and is indicated to aid in weight management in overweight and obese adults with a Body Mass Index (BMI) of 25-40 kg/m2, when used in conjunction with diet and exercise. Plenity passes through the digestive system, maintaining its three-dimensional structure in the stomach and small intestine before breaking down in the colon. This information might be about you, your preferences or your device. This information is advisory only and is not intended to replace sound clinical judgment in the delivery of healthcare services. Studies have demonstrated that OSH has modest weight loss efficacy and a favorable safety profile, with no significant difference in overall adverse events compared with placebo. This page cannot be displayed because your browser has been configured to The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This interaction can occur with the commonly used statins to lower cholesterol, like atorvastatin, lovastatin, or simvastatin. So when you speak with a health professional for your prescription, you can discuss the best times to take other meds. False-positive urine immunoassay screening tests for phencyclidine (PCP) and amphetamine have been reported in patients taking desvenlafaxine. As you continue to use it, you feel fuller throughout the day. We comply with the HONcode standard for trustworthy health information. Plenity(Superabsorbent Hydrogel Particles in Capsules) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. Plenity is a prescription-only weight loss aid. metformin efficacy (absorption possibly decreased), Monitoring Parameters This series is coordinated by Allen F. Shaughnessy, PharmD, assistant medical editor. Their average weight loss was 10% (about 22 pounds). + Epub 2018 Nov 13. Youll be asked to share your medical history and answer general health questions with a licensed physician to find out if Plenity is right for you. No related drugs found for this medication. Select one or more newsletters to continue. Is it available in my area? It may not be covered by all insurance plans and, because it is not considered a medication, it may not be covered in the future. An early response to therapy predicted clinically meaningful weight loss (i.e., 5% or more) at 24 weeks.2. You do not need to meet with a physician in person to get Plenity! You can also save 15% by purchasing a 12-week supply for $249. These rates are similar to those reported with a placebo. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Concomitant use of PRISTIQ with other serotonergic drugs increases the risk of serotonin syndrome. Other drugs may interact with Plenity, including prescription drugs and over-the-counter medicines, vitamins, and herbal products. Tell your health care provider about all of your medications including any supplements you are taking. Plenity is the trademark brand name for carboxymethyl cellulose and citric acid manufactured by Gelesis. Because Plenity should not be used without food (it is meant to be taken 2030 minutes before a meal), this Please e-prescribe Plenity to GoGoMeds Pharmacy in Southgate, KY, or plenity drug interactions medical device available only prescription! Urine immunoassay screening tests for phencyclidine ( PCP ) and amphetamine have been reported in patients desvenlafaxine. 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