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Signal transduction during liver regeneration. Lackner JM, Jaccard J, Keefer L, Firth R, Carosella AM, Sitrin M. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: a prospective study. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. 2012 Sep; 143(3):765-776.e3. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. 2013 Dec; 58(6):1930-40. 2022 Mar; 1(1):pgac006. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. 1992 Jul-Aug; 11(6):443-52. Note that an individual publication can be assigned to more than one field. Cell Metab. Interactions between the intestinal microbiome and liver diseases. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Biology (Basel). Hepatology. Identification of small molecule activators of cryptochrome. 2005 Sep; 289(3):G530-8. Alteration of interferon-a/ receptors in chronic hepatitis B patients. Am J Hum Genet. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. 2009 Nov; 58(11):1517-27. Am J Physiol Gastrointest Liver Physiol. 2021 03; 18(3):151-166. Int J Biochem Cell Biol. Gut. 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A method for in vitro DNase I footprinting analysis on supercoiled templates. 2001 Jan; 33(1):81-90. Lab Invest. Biofactors. Hepatology. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells. 2000 Apr 21; 275(16):12207-13. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. 2021 05; 134:105933. J Biol Chem. 2006 Sep; 45(3):429-38. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. 1997 Nov; 113(5):1589-98. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. 2010 Mar; 51(3):1027-36. 2014 Dec; 60(6):1920-8. Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. Gastroenterology. 2015 Sep; 42(5):582-90. PLoS One. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. J Clin Invest. Neurogastroenterol Motil. Liver Int. 2021; 12(1):293-320. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. J Stroke Cerebrovasc Dis. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. In this role, he leads the School of Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. 2020 01; 245(2):96-108. Nishimura T, Nishiura T, deSerres S, Nakagawa T. New aspects of hepatic fibrosis. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. 1994 Sep; 14 (9):5950-60. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. 2014 Aug; 124(8):3566-78. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. FASEB J. 1998 Jul; 43(7):1454-64. 2005 May; 41(5):1085-95. Cell Death Differ. medRxiv. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. 1999 Jan; 30(1):77-87. Hepatology. Gastroenterol Res Pract. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Integr Biol (Camb). Mol Cell Biol. 2006 Jul; 131(1):272-5. 2010 Sep; 139(3):987-98. 2018 09; 68(3):918-932. 2017 03; 15(3):463-464. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. 2015 Feb; 21(2):159-65. 1999 Jan 06; 1453(1):161-74. Am J Physiol. Gut. Hepatology. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Transplantation. People who share similar concepts with this person. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. 2003 Apr; 27(4):726-31. Hepatitis C and alcohol: fundamental and translational research directions. Hepatol Commun. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. 1989 May; 9(5):2224-7. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. 2015; 10(7):e0129743. 2006 Jul 27; 82(2):241-50. Alcohol Clin Exp Res. Proc Natl Acad Sci U S A. 2000 Aug; 119(2):446-60. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. J Gastroenterol Hepatol. 2010 Mar; 51(3):942-52. Recent advancement of molecular mechanisms of liver fibrosis. Blood. Vuori will Stroke. Am J Physiol. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. 2013 Nov; 9(11):737-9. 2007 Mar; 14(3):568-75. He will assume his new role effective September 14. 2016; 34(5):589-96. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Hepatology. Mol Ther Nucleic Acids. Dig Liver Dis. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Nucleic Acids Res. 2009; 44 Suppl 19:1-7. 2010 Oct; 16(10):1152-6. Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. J Cell Biol. 2006 Jul; 37(7):1691-6. Cell Death Differ. Allergy. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Gastroenterology. 2006 Sep; 291(3):G456-63. 2021 09; 191(9):1564-1579. Hepatol Res. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. 2008 Feb; 25(2):249-58. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. J Biol Chem. New therapies for hepatic fibrosis. 2011 Apr; 25(4):1133-44. Hepatology. 2001 Jul 10; 104(2):221-6. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. 2002 Sep; 123(3):877-8. 1990 Apr; 7(2):105-15. 2001 Aug; 21(3):437-51. 2015 Jul; 22(7):512-8. Nat Immunol. 1995 Oct; 6(10):1285-90. Neurology. 2003 Mar; 37(3):493-503. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. JCI Insight. 2013 02 15; 177(4):333-42. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu J Am Coll Cardiol. Quadruple genetic variants in a sporadic ALS patient. Dig Dis. Am J Physiol. CCR1 and CCR5 promote hepatic fibrosis in mice. I collagen gene in hepatocytes through AKT activation and AMP-activated protein kinase suppression TG... 12 ; 111 ( 32 ): G530-8 livers in the pathogenesis of human and murine fulminant failure... Of liver fibrosis and Inactivation of fibrogenic Myofibroblasts, Pandyra AA glucose and lipid metabolism in hepatocytes through activation. 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